There is another huge handicapping angle the pros use in Las Vegas. If a team wins by more than 21 points, the sharpies bet against that team the following week.
Same thing when a team loses by 21 or more points-they bet on that team the following week.
The theory is the good teams will have a much higher number the following week and the losers will be getting more points than they should get...or giving less if they are the favorite.
This was a close to 70% angle for ten years last time I checked the stats.